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  • 產(chǎn)品名稱： Ansamitocin P-0
  • 產(chǎn)品貨號(hào)： CS00034
  • 貨期： 現(xiàn)貨
  • 價(jià)格與訂購(gòu)： 1050
  • 數(shù)量：
    庫(kù)存： 10
  • 規(guī)格： 10mg
  • 產(chǎn)品信息
  • 如何訂購(gòu)
    產(chǎn)品描述
    Maytansinol inhibits microtubule assembly and causes microtubule disassembly in vitro. 
    靶點(diǎn)活性
    Maytansinoids
    體外活性
    Maytansinol inhibits the growth of HCT116 human colon cancer cells. Maytansinol causes apoptosis in imaginal discs of wild-type larvae but not p53 mutant larvae. Maytansinol induces apoptosis in imaginal discs of wild-type larvae but not p53 mutant larvae at 24 hours after exposure to the drug. Maytansinol decreases the growth and/or survival of HCT116 cells in a dose-dependent manner and that the effect was more severe for p53+/+ than for p53-/- cells at both low and high doses. Maytansinol disrupts the mitotic spindle and prevents mitotic exit in Drosophila. This parallels the finding in human HCT116 cells, in which Maytansinol was more effective when p53 was present, at least at some doses. 
    別名
    Ansamitocin P-0 , 美登醇
    純度
    98%
    分子量
    565.06 
    分子式
    C28H37ClN2O8
    CAS No.
    57103-68-1 
    存儲(chǔ)
    Powder: -20°C for 3 years
    In solvent: -80°C for 2 years
    溶解度
    DMSO: 35 mg/mL (61.94 mM)
    ( < 1 mg/ml refers to the product slightly soluble or insoluble )
    參考文獻(xiàn)
    1. Edwards A, et al. Combinatorial effect of maytansinol and radiation in Drosophila and human cancer cells. Dis Model Mech. 2011 Jul;4(4):496-503.
    Note
    For research use only .