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  • 產(chǎn)品名稱： Research Grade Nivolumab ( 納武單抗 )
  • 產(chǎn)品貨號： CSD00292
  • 貨期： 現(xiàn)貨
  • 價格與訂購： 2480
  • 數(shù)量：
    庫存： 10
  • 規(guī)格： 100μg
  • 產(chǎn)品信息
  • 如何訂購
    貨號（Catalog No.）
    CSD00292
    通用名INN
    Nivolumab
    純度(Purity)
    >95%
    濃度( Concentration)
    1mg/ml
    Formulation
    PBS buffer PH7.5
    Source
    CHO cells
    內(nèi)毒素(Endotoxin level)
    Please contact with the lab for this information.
    產(chǎn)品描述(Description)

    Nivolumab is a programmed death receptor-1 (PD-1) blocking antibody to treat advanced (metastatic) non-small cell lung cancer.

    別名(Alternative names)
    BMS-936558,MDX-1106,ONO-4538
    靶點;物種(Specificity target name;species)
    PDCD1/PD1/CD279[Homo sapiens]
    活性研究（體外/體內(nèi)研究）(Activity in vitro)
    Nivolumab binds to CHO cells expressing PD-1 with an EC50 of 1.66 nM, but does not bind to the parental CHO cell line. Nivolumab binds to PD-1 on activated T cells with an EC50 of 0.64 nM. Nivolumab also inhibits the interaction between PD-1 and its ligands, PD-L1 and PD-L2, with IC50 values of 2.52 and 2.59 nM, respectively. Nivolumab (1.5 ng/mL) can enhance T-cell reactivity in the presence of a T-cell receptor stimulus.
    種類(Species)
    Homo sapiens
    受體鑒定(Receptor identification)
    IgG4-kappa
    分子量(MV)
    143599.09 Da
    CAS
    946414-94-4
    存儲條件(Storage)
    Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
    Store at +4°C short term (1-2 weeks).
    Store at -20 °C 12 months.
    Store at -80°C long term.
    Note
    For research use only .