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  • 產(chǎn)品名稱： KL-11743
  • 產(chǎn)品貨號(hào)： CS01459
  • 貨期： 現(xiàn)貨
  • 價(jià)格與訂購(gòu)： 1500
  • 數(shù)量：
    庫(kù)存： 10
  • 規(guī)格： 5mg
  • 產(chǎn)品信息
  • 如何訂購(gòu)
    產(chǎn)品描述
    KL-11743 is a potent, orally active, and glucose-competitive inhibitor of the class I glucose transporters, with IC50s of 115, 137, 90, and 68 nM for GLUT1, GLUT2, GLUT3, and GLUT4, respectively. KL-11743 specifically blocks glucose metabolism. KL-11743 can synergize with electron transport inhibitors to induce cell death[1][2][3].
    分子量
    522.60
    分子式
    C30H30N6O3
    結(jié)構(gòu)式
    CAS No.
    1369452-53-8
    性狀
    固體
    顏色
    Light yellow to green yellow
    純度
    98%
    運(yùn)輸條件
    Room temperature in continental US; may vary elsewhere.
    儲(chǔ)存條件
    Powder: -20°C for 3 years，4°C for 2 years ；In solvent: -80°C for 6 montha，-20°C for  1 month|.
    參考文獻(xiàn)
    [1]. Liu KG, et, al. Discovery and Optimization of Glucose Uptake Inhibitors. J Med Chem. 2020 May 28;63(10):5201-5211.
    [2]. Liu X, et, al. Cystine transporter regulation of pentose phosphate pathway dependency and disulfide stress exposes a targetable metabolic vulnerability in cancer. Nat Cell Biol. 2020 Apr;22(4):476-486.
    [3]. Olszewski K, et, al. Inhibition of glucose transport synergizes with chemical or genetic disruption of mitochondrial metabolism and suppresses TCA cycle-deficient tumors. Cell Chem Biol. 2021 Oct 22;S2451-9456(21)00441-4.
    Note
    For research use only.