瀏覽量: 94
- 產(chǎn)品名稱: Research Grade Cibisatamab ( 賽必妥單抗 )
- 產(chǎn)品貨號(hào): CSD00536
- 貨期: 現(xiàn)貨
- 價(jià)格與訂購(gòu): 2480
- 數(shù)量:
- 規(guī)格: 100μg
- 產(chǎn)品信息
- 如何訂購(gòu)
貨號(hào)(Catalog No.)
CSD00536
通用名INN
Cibisatamab
純度(Purity)
>95%
濃度( Concentration)
1mg/ml
Formulation
PBS buffer PH7.5
Source
CHO cells
內(nèi)毒素(Endotoxin level)
Please contact with the lab for this information.
產(chǎn)品描述(Description)
Cibisatamab(CEA-TCB)是一種T細(xì)胞雙特異性抗體,結(jié)合癌細(xì)胞上的癌胚抗原(CEA)和T細(xì)胞上的CD3。Cibisatamab在T細(xì)胞上有1個(gè)CD3ε鏈的單結(jié)合位點(diǎn)和2個(gè)CEA結(jié)合位點(diǎn)(其調(diào)節(jié)對(duì)細(xì)胞表面CEA中高表達(dá)的癌細(xì)胞的結(jié)合親和力)。這避免了靶向具有低CEA表達(dá)水平的健康上皮細(xì)胞。通過(guò)與癌細(xì)胞表面上的CEA和T細(xì)胞上的CD3的結(jié)合引發(fā)T細(xì)胞活化,細(xì)胞因子分泌和細(xì)胞毒性顆粒釋放。
別名(Alternative names)
CEA TCB,RG-7802,RO-6958688
靶點(diǎn);物種(Specificity target name;species)
CD3E/CEACAM5[Homo sapiens]
種類(lèi)(Species)
Humanized
受體鑒定(Receptor identification)
IgG1-kappa/lambda with domain crossover
CAS
2101242-53-7
存儲(chǔ)條件(Storage)
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
Store at +4°C short term (1-2 weeks).
Store at -20 °C 12 months.
Store at -80°C long term.
Note
For research use only .