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  • 產(chǎn)品名稱： Research Grade HuMax-IL8
  • 產(chǎn)品貨號(hào)： CSD00668
  • 貨期： 現(xiàn)貨
  • 價(jià)格與訂購(gòu)： 2480
  • 數(shù)量：
    庫(kù)存： 100
  • 規(guī)格： 100μg 200μg 1mg
  • 產(chǎn)品信息
  • 如何訂購(gòu)
    貨號(hào)（Catalog No.）
    CSD00668
    通用名INN
    BMS-986253, HuMax-IL8, HuMax-Inflam/MDX018
    純度(Purity)
    >95%
    濃度( Concentration)
    1mg/ml
    Formulation
    PBS buffer PH7.5
    Source
    CHO cells
    內(nèi)毒素(Endotoxin level)
    Please contact with the lab for this information.
    生物活性
    產(chǎn)品描述(Description)
    HuMax-IL8(BMS-986253) is a novel fully human monoclonal antibody that binds to and inhibits IL-8, a chemokine that promotes immune escape and tumor progression.
    別名(Alternative names)
    BMS-986253, HuMax-IL8, HuMax-Inflam/MDX018
    靶點(diǎn);物種(Specificity target name;species)
    IL-8(Granulocyte chemotactic protein 1，Monocyte-derived neutrophil-activating peptide，IL-8(1-77)，IL-8(9-77)，Monocyte-derived neutrophil chemotactic factor，IL-8(7-77)，(Ser-IL-8)72，GCP/IL-8 protein V，MONAP，C-X-C motif chemokine 8，GCP/IL-8 protein I，Neutrophil-ac ) [Homo sapiens]
    靶點(diǎn)背景信息(Target information)
    Interleukin 8 (IL8 or chemokine (C-X-C motif) ligand 8, CXCL8) is a chemokine produced by macrophages and other cell types such as epithelial cells, airway smooth muscle cells and endothelial cells. There are many receptors on the surface membrane capable of binding IL-8, the most frequently studied types are the G protein-coupled serpentine receptors CXCR1 and CXCR2. Expression and affinity for IL-8 differs between the two receptors (CXCR1 > CXCR2). IL-8(6-77) has a 5-10-fold higher activity on neutrophil activation, IL-8(5-77) has increased activity on neutrophil activation and IL-8(7-77) has a higher affinity to receptors CXCR1 and CXCR2 as compared to IL-8(1-77), respectively.
    種類(Species)
    Humanized
    受體鑒定(Receptor identification)
    IgG1
    化學(xué)信息
    分子量(MV)
    150000.00 Da
    存儲(chǔ)條件(Storage)
    Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
    Store at +4°C short term (1-2 weeks).
    Store at -20 °C 12 months.
    Store at -80°C long term.
    Note
    For research use only .