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  • 產品名稱： Recombinant Human NFKBIA protein
  • 產品貨號： CSP00504
  • 貨期： 現貨
  • 價格與訂購： 1800
  • 數量：
    庫存： 100
  • 規(guī)格： 50μg 100μg 1mg
  • 產品信息
  • 如何訂購
    概述（Summary）
    英文全稱
    Recombinant Human NFKBIA protein
    純度（Purity）
    >90% as determined by SDS-PAGE
    內毒素（Endotoxin level）
    Please contact with the lab for this information.
    蛋白構建（Construction）
    A DNA sequence encoding the human NFKBIA (Lys67-Glu302) was fused with His tag
    Accession #
    P25963
    表達宿主（Host）
    E.coli
    種屬（Species）
    Homo sapiens (Human)
    預測分子量（Predicted Molecular Mass）
    27.2 kDa
    制劑（Formulation）
    Supplied as solution form in PBS pH 7.5 or lyophilized from PBS pH 7.5.
    運輸方式（Shipping）
    In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
    穩(wěn)定性&儲存（Stability &Storage）
    Use a manual defrost freezer and avoid repeated freeze thaw cycles.
    Store at 2 to 8 °C for one week .
    Store at -20 to -80 °C for twelve months from the date of receipt.
    復溶（Reconstitution）
    Reconstitute in sterile water for a stock solution.A copy of datasheet will be provided with the products, please refer to it for details.
    背景（Background）
    背景介紹
    Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha (IkB alpha, NFKBIA, or IKBA), is a member of the NF-kappa-B inhibitor family that function to inhibit the NF-kB transcription factor. NFKBIA inhibits NF-kB by masking the nuclear localization signals (NLS) of NF-kB proteins and keeping them sequestered in an inactive state in the cytoplasm. In addition, NFKBIA blocks the ability of NF-κB transcription factors to bind to DNA, which is required for NF-kB's proper functioning. Signal-induced degradation of I kappa B alpha exposes the nuclear localization signal of NF-kappa B, thus allowing it to translocate into the nucleus and activate transcription from responsive genes. An autoregulatory loop is established when NF-kappa B induces expression of the I kappa B alpha gene and newly synthesized I kappa B alpha accumulates in the nucleus where it negatively regulates NF-kappa B-dependent transcription. As part of this post-induction repression, the nuclear export signal on I kappa B alpha mediates transport of NF-kappa B-I kappa B alpha complexes from the nucleus to the cytoplasm. Deletion of NFKBIA has an effect that is similar to the effect of EGFR amplification in the pathogenesis of glioblastoma and is associated with comparatively short survival. Polymorphisms in NFKBIA may be important in pre-disposition to and outcome after treatment, of multiple myeloma (MM). The NFKBIA gene product, IkappaBalpha, binds to NF-kappaB preventing its activation and is important in mediating resistance to apoptosis in B-cell lymphoproliferative diseases.
    分子別名（Alternative Names）
    NF-kappa-B inhibitor alpha,I-kappa-B-alpha,IkB-alpha,IkappaBalpha,Major histocompatibility complex enhancer-binding protein MAD3.
    Note
    For research use only .