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  • 產(chǎn)品名稱： Recombinant Human UCHL1 protein
  • 產(chǎn)品貨號： CSP01190
  • 貨期： 現(xiàn)貨
  • 價格與訂購： 1800
  • 數(shù)量：
    庫存： 100
  • 規(guī)格： 50μg 100μg 1mg
  • 產(chǎn)品信息
  • 如何訂購
    英文全稱
    Recombinant Human UCHL1 protein
    純度（Purity）
    >90% as determined by SDS-PAGE
    內(nèi)毒素（Endotoxin level）
    Please contact with the lab for this information.
    蛋白構(gòu)建（Construction）
    A DNA sequence encoding the human UCHL1 (Gln2-Ala223) was fused with His tag
    Accession #
    P09936
    表達宿主（Host）
    E.coli
    種屬（Species）
    Homo sapiens (Human)
    預測分子量（Predicted Molecular Mass）
    26.08 kDa
    制劑（Formulation）
    Supplied as solution form in PBS pH 7.5 or lyophilized from PBS pH 7.5.
    運輸方式（Shipping）
    In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
    穩(wěn)定性&儲存（Stability &Storage）
    Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8 °C for one week .
    Store at -20 to -80 °C for twelve months from the date of receipt.
    復溶（Reconstitution）
    Reconstitute in sterile water for a stock solution.A copy of datasheet will be provided with the products, please refer to it for details.
    背景介紹
    Ubiquitin carboxyl-terminal hydrolase isozyme L1, also known as UCH-L1, Ubiquitin thioesterase L1, PGP9.5 and UCHL1, is a deubiqutinating enzyme with important functions in recycling of ubiquitin. Regulated proteolysis by the ubiquitin pathway has been implicated in control of the cell cycle, transcriptional activation, cell fate and growth, and synaptogenesis. The ubiquitin-proteasome system is involved in synaptic plasticity and is proposed to be part of a molecular switch that converts short-term synaptic potentiation to long-term changes in synaptic strength. UCHL1 is found in neuronal cell bodies and processes throughout the neocortex (at protein level). It is expressed in neurons and cells of the diffuse neuroendocrine system and their tumors. UCHL1 is weakly expressed in ovary. UCHL1 is a ubiquitin-protein hydrolase. It is involved both in the processing of ubiquitin precursors and of ubiquitinated proteins. This enzyme is a thiol protease that recognizes and hydrolyzes a peptide bond at the C-terminal glycine of ubiquitin. UCHL1 also binds to free monoubiquitin and may prevent its degradation in lysosomes. The homodimer of UCHL1 may have ATP-independent ubiquitin ligase activity. UCHL1 dysfunction has been associated with neurodegeneration in Parkinson's, Alzheimer's, and Huntington's disease patients. Reduced UCHL1 function may jeopardize the survival of CNS neurons.
    分子別名（Alternative Names）
    Ubiquitin carboxyl-terminal hydrolase isozyme L1,UCH-L1,Neuron cytoplasmic protein 9.5,PGP 9.5,PGP9.5,Ubiquitin thioesterase L1.
    Note
    For research use only.