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- 產(chǎn)品名稱： Recombinant Human PIK3CA protein
- 產(chǎn)品貨號(hào)： CSP01542
- 貨期： 現(xiàn)貨
- 價(jià)格與訂購(gòu)： 1800
- 數(shù)量：
庫(kù)存： 100
- 規(guī)格： 50μg 100μg 1mg
- 產(chǎn)品信息
- 如何訂購(gòu)
概述（Summary）
英文全稱
Recombinant Human PIK3CA protein
純度（Purity）
>90% as determined by SDS-PAGE
內(nèi)毒素（Endotoxin level）
Please contact with the lab for this information.
蛋白構(gòu)建（Construction）
A DNA sequence encoding the human PIK3CA (Asn345-Phe550) was fused with His tag
Accession #
P42336
表達(dá)宿主（Host）
E.coli
種屬（Species）
Homo sapiens (Human)
預(yù)測(cè)分子量（Predicted Molecular Mass）
24.16 kDa
制劑（Formulation）
Supplied as solution form in PBS pH 7.5 or lyophilized from PBS pH 7.5.
運(yùn)輸方式（Shipping）
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
穩(wěn)定性&儲(chǔ)存（Stability &Storage）
Use a manual defrost freezer and avoid repeated freeze thaw cycles.
Store at 2 to 8 °C for one week .
Store at -20 to -80 °C for twelve months from the date of receipt.
Store at 2 to 8 °C for one week .
Store at -20 to -80 °C for twelve months from the date of receipt.
復(fù)溶（Reconstitution）
Reconstitute in sterile water for a stock solution.A copy of datasheet will be provided with the products, please refer to it for details.
背景（Background）
背景介紹
Phosphoinositide-3-kinase (PI3K) that phosphorylates PtdIns (Phosphatidylinositol), PtdIns4P (Phosphatidylinositol 4-phosphate) and PtdIns(4,5)P2 (Phosphatidylinositol 4,5-bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3). PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival, proliferation, motility and morphology. Participates in cellular signaling in response to various growth factors. Involved in the activation of AKT1 upon stimulation by receptor tyrosine kinases ligands such as EGF, insulin, IGF1, VEGFA and PDGF. Involved in signaling via insulin-receptor substrate (IRS) proteins. Essential in endothelial cell migration during vascular development through VEGFA signaling, possibly by regulating RhoA activity. Required for lymphatic vasculature development, possibly by binding to RAS and by activation by EGF and FGF2, but not by PDGF. Regulates invadopodia formation through the PDPK1-AKT1 pathway. Participates in cardiomyogenesis in embryonic stem cells through a AKT1 pathway. Participates in vasculogenesis in embryonic stem cells through PDK1 and protein kinase C pathway. Also has serine-protein kinase activity: phosphorylates PIK3R1 (p85alpha regulatory subunit), EIF4EBP1 and HRAS. Plays a role in the positive regulation of phagocytosis and pinocytosis.
分子別名（Alternative Names）
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform,Short name:
PI3-kinase subunit alpha,Short name:PI3K-alpha,Short name:
PI3KalphaShort name:PtdIns-3-kinase subunit alpha,Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit alpha,Short name:PtdIns-3-kinase subunit p110-alpha,Short name:p110alpha,Phosphoinositide-3-kinase catalytic alpha polypeptide,Serine/threonine protein kinase PIK3CA
PI3-kinase subunit alpha,Short name:PI3K-alpha,Short name:
PI3KalphaShort name:PtdIns-3-kinase subunit alpha,Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit alpha,Short name:PtdIns-3-kinase subunit p110-alpha,Short name:p110alpha,Phosphoinositide-3-kinase catalytic alpha polypeptide,Serine/threonine protein kinase PIK3CA
Note
For research use only .
地 址：
產(chǎn)品銷售：
E - mail ：
郵 編：
Amily
