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  • 產(chǎn)品名稱： Research Grade Anti CD146/MUC18 (c3.19.1)
  • 產(chǎn)品貨號(hào)： CSD00714
  • 貨期： 現(xiàn)貨
  • 價(jià)格與訂購(gòu)： 2480
  • 數(shù)量：
    庫(kù)存： 100
  • 規(guī)格： 100μg
  • 產(chǎn)品信息
  • 如何訂購(gòu)
    貨號(hào)（Catalog No.）
    CSD00714
    純度(Purity)
    >95%
    濃度( Concentration)
    1mg/ml
    Formulation
    PBS buffer PH7.5
    Source
    XtenCHO
    內(nèi)毒素(Endotoxin level)
    Please contact with the lab for this information.
    生物活性
    產(chǎn)品描述(Description)
    c3.19.1refers to a fully human IgG2 monoclonal antibody directed against the MUC18 antigen. The antibody was generated using XenoMouse? technology (Abgenix, Inc. Fremont, Calif.) and consists of human gamma 2 heavy and kappa light chains with a molecular weight of approximately 150 kDa.
    別名(Alternative names)
    c3.19.1
    靶點(diǎn);物種(Specificity target name;species)
    CD146/MUC18[Homo sapiens]
    靶點(diǎn)背景信息(Target information)
    CD146, also known as the melanoma cell adhesion molecule (MCAM) or cell surface glycoprotein MUC18, is a 113kDa cell adhesion molecule currently used as a marker for endothelial cell lineage. As a member of the Immunoglobulin superfamily, It is expressed on chicken embryonic spleen and thymus, activated human T cells, endothelial progenitors such as angioblasts and mesenchymal stem cells, and strongly expressed on blood vessel endothelium and smooth muscle. CD146 has been demonstrated to appear on a small subset of T and B lymphocytes in the peripheral blood of healthy individuals. The CD146+ T cells display an immunophenotype consistent with effector memory cells and have a distinct gene profile from the CD146- T cells. As a Ca2+ independent cell adhesion molecule involved in heterophilic cell to cell interactions and a surface receptor,CD146 triggers tyrosine phosphorylation of FYN and PTK2 and subsequently induced signal transduction, proteolysis or immune recognition.
    種類(Species)
    Humanized
    受體鑒定(Receptor identification)
    Human IgG2
    化學(xué)信息
    分子量(MV)
    150000.00 Da
    存儲(chǔ)條件(Storage)
    Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
    Store at +4°C short term (1-2 weeks).
    Store at -20 °C 12 months.
    Store at -80°C long term.
    Note
    For research use only .