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  • 產(chǎn)品名稱： Thrombin (MW 37kDa)
  • 產(chǎn)品貨號： CSGC61495
  • 貨期： 現(xiàn)貨
  • 價格與訂購： 1600
  • 數(shù)量：
    庫存： 10
  • 規(guī)格： 1000U 2000U
  • 產(chǎn)品信息
  • 如何訂購
    產(chǎn)品描述
    Thrombin (MW 37kDa) is a Na+-activated, allosteric serine protease. Thrombin induces the activation of ERK1 and ERK2[1]. Thrombin recognition sequence and can be used to digest GST-tagged proteins[2].Thrombin could activate the immune system by directly cleaving pro-interleukin-1α to the active form (IL-1α) [3]. Thrombin may be “a gas pedal” driving the innate immune system[4].
    Cas No.
    9002-04-4
    Canonical SMILES
    [Thrombin]
    分子量
    37000(Average)
    儲存條件
    4°C, protect from light
    General tips
    請根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲備液；一旦配成溶液，請分裝保存，避免反復(fù)凍融造成的產(chǎn)品失效。
    純度
    >98.00%
    儲備液的保存方式和期限
    -80°C 儲存時，請在 6 個月內(nèi)使用，-20°C 儲存時，請在 1 個月內(nèi)使用。為了提高溶解度，請將管子加熱至37℃，然后在超聲波浴中震蕩一段時間。
    參考文獻(xiàn)
    [1]. Kramer RM, Roberts EF, et,al. Differential activation of cytosolic phospholipase A2 (cPLA2) by thrombin and thrombin receptor agonist peptide in human platelets. Evidence for activation of cPLA2 independent of the mitogen-activated protein kinases ERK1/2. J Biol Chem. 1995 Jun 16;270(24):14816-23. doi: 10.1074/jbc.270.24.14816. PMID: 7782348.
    [2]. Golderman V, Shavit-Stein E, et,al. Thrombin and the Protease-Activated Receptor-1 in Organophosphate-Induced Status Epilepticus. J Mol Neurosci. 2019 Feb;67(2):227-234. doi: 10.1007/s12031-018-1228-6. Epub 2018 Dec 4. PMID: 30515700.
    [3]. Burzynski LC, Humphry M, et,al. The Coagulation and Immune Systems Are Directly Linked through the Activation of Interleukin-1α by Thrombin. Immunity. 2019 Apr 16;50(4):1033-1042.e6. doi: 10.1016/j.immuni.2019.03.003. Epub 2019 Mar 26. PMID: 30926232; PMCID: PMC6476404.
    [4]. Petzold T, Massberg S. Thrombin: A Gas Pedal Driving Innate Immunity. Immunity. 2019 Apr 16;50(4):1024-1026. doi: 10.1016/j.immuni.2019.03.006. PMID: 30995493. 
    Note
    For research use only .